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Idiopathic Subglottic Stenosis (ISS)

Idiopathic subglottic stenosis (ISS) is a condition characterized by narrowing of the subglottic region of the airway, which is located just below the vocal cords.

 

Here are some key points about ISS:

 

• Causes

- Idiopathic Nature: The exact cause is unknown, but it may involve factors like inflammation, scarring, or genetic predispositions.

- Associated Conditions: Some cases may be linked to conditions such as gastroesophageal reflux disease (GERD) or chronic inflammation.

 

• Symptoms

- Breathing Difficulties: Patients often experience stridor (a wheezing sound during breathing), especially when exerting themselves.

- Voice Changes: Hoarseness or changes in voice can occur.

- Cough: A persistent cough may be present.

 

• Diagnosis

- Laryngoscopy: This is often the first step, where a doctor examines the airway using a flexible tube with a camera.

- Imaging: CT scans may be used to assess the extent of the stenosis.

 

• Treatment

- Conservative Management: Observation may be appropriate for mild cases.

- Surgical Options: In more severe cases, procedures like dilation, laser surgery, or tracheostomy may be necessary to alleviate obstruction.

- Steroid Therapy: Inflammation management using corticosteroids may also be part of the treatment plan.

 

• Prognosis

- The outlook can vary. Some patients may have persistent symptoms, while others respond well to treatment. Regular follow-up is essential to monitor the condition.

There is no cure for this condition, most patients have to do surgeries, resections or steroid injections to prolong life.

I look forward to sharing my story for catharsis and awareness.

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"Idiopathic subglottic stenosis (iSGS) is a rare condition that predominantly affects women, with studies showing 96% to 98% of cases occurring in females (Journal of Otolaryngology)." "The estimated incidence of iSGS is approximately 1 in 400,000 individuals (Journal of Thoracic Disease)

References

  1. Mueller, S. K., et al. (2021). Idiopathic subglottic stenosis: Etiology, management, and outcomes. Journal of Otolaryngology - Head & Neck Surgery. Retrieved from https://journalotohns.biomedcentral.com/articles/10.1186/s40463-021-00544-8

  2. Nouraei, S. A. R., et al. (2020). Subglottic stenosis and idiopathic airway narrowing. Journal of Thoracic Disease. Retrieved from https://jtd.amegroups.org/article/view/34764/html

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